September 26, 2022

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Mapping Brain Stem’s Control of Eating Could Lead to Better Treatments for Obesity

Mapping Brain Stem’s Control of Eating Could Lead to Better Treatments for Obesity

Summary: Researchers investigate neural pathways that meet in the brainstem which help control feeding behaviors.

Source: University of Michigan

Every meal you sit down to makes an impression, with foods filed away as something delicious to be sought out again, or to be avoided in disgust if we associate the flavor with gut malaise.

How this decision is made turns out to be so fundamental to our well-being—determining what foods to seek and avoid—that the signals are coordinated within the most primitive parts of our brains, the brain stem or hindbrain. This brain region also helps us decide when we are “full” and should stop eating.

To date, scientists interested in how and why people gain weight and the diseases that can result from overeating and obesity have focused on a part of the brain called the hypothalamus, following discoveries of two intertwined systems that play important roles in controlling energy balance, the leptin and melanocortin systems.

A paper in the journal Nature Metabolism looks outside this brain region and reviews the various brain pathways that meet in the brain stem to control feeding behavior, using a technique that offers an unbiased look at the neurons involved.

“Everything the hypothalamus does ends up converging in the brainstem. The brain stem is super important in the control of feeding because it takes all sorts of information from your gut, including whether the stomach is distended and whether nutrients have been ingested, and integrates this with information from the hypothalamus about nutritional needs before passing it all on to the rhythmic pattern generators that control food intake,” said Martin Myers, Jr., M.D., Ph.D., professor of Internal medicine and Molecular & Integrative Physiology and director of the Elizabeth Weiser Caswell Diabetes Institute.

The recent review builds on recent findings in mice from the Myers lab that revealed the existence of two different food intake-suppressing brain stem circuits- one that causes nausea and disgust, and one that does not, as well as from collaborations with colleague Tune Pers, Ph.D., of the University of Copenhagen. Pers and his group used single cell mapping of brain cells within the dorsal vagal complex, a region in the brain stem that mediates a host of unconscious processes, including feelings of satiety (or sickness) after eating.

Mapping Brain Stem’s Control of Eating Could Lead to Better Treatments for Obesity
He notes that many of these cell populations are targets for new and effective anti-obesity drugs— for example, a class of drugs for diabetes called GLP1 receptor agonists that can lower blood sugar and help you eat less. Image is in the public domain

The new review paper, from first author Wenwen Cheng, Ph.D., Myers, Pers, and their colleagues, integrates these findings with other recent discoveries to build a new model of brainstem neuronal circuits and how they control food intake and nausea.

“Taking all of this information together allows us to predict which set of neurons control this or that function,” said Myers.

He notes that many of these cell populations are targets for new and effective anti-obesity drugs— for example, a class of drugs for diabetes called GLP1 receptor agonists that can lower blood sugar and help you eat less.

“There is a population of GLP1 neurons in the brain stem which, if you turn them on, will stop food intake but cause violent illness, but there may be another population of neurons that stops eating without making you feel badly.”

Having a detailed map of these neurons and understanding the effects of modifying these cell targets, Myers explains, can assist in making drugs with fewer negative side effects.

About this neuroscience research news

Author: Press Office
Source: University of Michigan
Contact: Press Office – University of Michigan
Image: The image is in the public domain

See also

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Original Research: Closed access.
Hindbrain circuits in the control of eating behaviour and energy balance” by Wenwen Cheng et al. Nature Metabolism


Abstract

Hindbrain circuits in the control of eating behaviour and energy balance

Body weight and adiposity represent biologically controlled parameters that are influenced by a combination of genetic, developmental and environmental variables.

Although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now recognized that neuronal circuits in the hindbrain not only serve to produce nausea and to terminate feeding in response to food consumption or during pathological states, but also contribute to the long-term control of body weight.

Additionally, recent work has identified hindbrain neurons that are capable of suppressing food intake without producing aversive responses like those associated with nausea. Here we review recent advances in our understanding of the hindbrain neurons that control feeding, particularly those located in the area postrema and the nucleus tractus solitarius.

We frame this information in the context of new atlases of hindbrain neuronal populations and develop a model of the hindbrain circuits that control food intake and energy balance, suggesting important areas for additional research.

Mapping Brain Stem’s Control of Eating Could Lead to Better Treatments for Obesity